Everyone has personal experience with the 'miracle" vaccines used from 2019 - 2021. The MRNA delivery mechanism for those and other MRNA medications uses nanoparticles in which the MRNA is embedded. These nanoparticles can cross the cell membrane about 7% of the time so relatively large doses are needed for delivery. These nanoparticles are also highly toxic and cause severe side effects that are frequently as bad or worse than the ailment they are meant to prevent or treat. The nanoparticles also suffer from long tissue persistence, exacerbating their toxicity. Many MRNA therapeutics could be unlocked if the persistence and toxicity could be limited.
This new research paper, that was published in Nature, explains experiments that show promise of an approach the authors discovered to mitigating nanoparticle persistence and therefore the toxicity issues.
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